关键字：2007ESC   心肌梗死   NADPH氧化酶   基因   血小板

编者按：本文详细阐述了有关与氧化酵素有关的基因多态性影响早发心肌梗死的危险性的研究。

Polymorphism may modify MI risk in young people A GENETIC polymorphism associated with the enzyme NADPH oxidase is related to the development of premature myocardial infarction (MI), aA component of this enzyme is the gene, p22PHOX, which plays a critical role in the generation of reactive oxygen species (ROS). p22PHOX is found in phagocytes, vascular cells and platelets, and it contains one of the potential NADPH oxidase heme binding sites that are indispensable for enzyme activation and function. The genetic polymorphism C242T occurs in the p22PHOX gene when histidine is replaced by tyrosine at amino a